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Neuron. 2015 Sep 2;87(5):1036-49. doi: 10.1016/j.neuron.2015.07.025. Epub 2015 Aug 13.

Multimodal Chemosensory Circuits Controlling Male Courtship in Drosophila.

Author information

1
Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY 10065, USA.
2
Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
3
Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, NY 10065, USA. Electronic address: ruta@rockefeller.edu.

Abstract

Throughout the animal kingdom, internal states generate long-lasting and self-perpetuating chains of behavior. In Drosophila, males instinctively pursue females with a lengthy and elaborate courtship ritual triggered by activation of sexually dimorphic P1 interneurons. Gustatory pheromones are thought to activate P1 neurons but the circuit mechanisms that dictate their sensory responses to gate entry into courtship remain unknown. Here, we use circuit mapping and in vivo functional imaging techniques to trace gustatory and olfactory pheromone circuits to their point of convergence onto P1 neurons and reveal how their combined input underlies selective tuning to appropriate sexual partners. We identify inhibition, even in response to courtship-promoting pheromones, as a key circuit element that tunes and tempers P1 neuron activity. Our results suggest a circuit mechanism in which balanced excitation and inhibition underlie discrimination of prospective mates and stringently regulate the transition to courtship in Drosophila.

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PMID:
26279475
PMCID:
PMC4560615
DOI:
10.1016/j.neuron.2015.07.025
[Indexed for MEDLINE]
Free PMC Article

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