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Psychiatry Res. 2015 Oct 30;229(3):901-4. doi: 10.1016/j.psychres.2015.07.041. Epub 2015 Aug 7.

Parameters of glucose and lipid metabolism at the fasted state in drug-naïve first-episode patients with psychosis: Evidence for insulin resistance.

Author information

1
Department of Psychiatry, Medical School, University of Ioannina, P.O. Box 1186, 45110 Ioannina, Greece. Electronic address: ppetrikis@hotmail.gr.
2
Department of Endocrinology, Medical School, University of Ioannina, 45110 Ioannina, Greece.
3
Department of Computer Engineering, School of Applied Technology, Technological Educational Institute of Epirus, 47100 Arta, Greece.
4
Department of Psychiatry, Medical School, University of Ioannina, P.O. Box 1186, 45110 Ioannina, Greece.

Abstract

Diabetes and dyslipidemia are common in patients with psychosis; this association may be partly related to adverse metabolic effects of antipsychotic medications. We assessed glucose and lipid metabolism during the fasted state in drug-naïve patients with psychosis. Fasting serum concentrations of total cholesterol, triglycerides, high density lipoprotein (HDL), glucose, insulin, connecting peptide (C-peptide), homeostatic model assessment index (HOMA-IR), glycated hemoglobin (HbA1C) and serum cortisol were compared between a group of 40 newly diagnosed drug-naïve, first-episode patients with psychosis and a group of 40 healthy controls, matched for age, sex and BMI. Total cholesterol, triglycerides and fasting glucose levels were similar, whereas insulin and C-peptide levels were higher and HDL marginally lower in the patients' group compared to those in healthy controls. Drug-naïve patients with psychosis were more insulin resistant (as assessed by the HOMA-R index) compared to healthy controls. Serum cortisol did not differ between the two groups. There is evidence that drug-naïve, first-episode patients with psychosis are more insulin resistant compared to healthy controls.

KEYWORDS:

Cholesterol; Diabetes; Dyslipidemia; First-episode; Metabolism; Schizophrenia

PMID:
26279127
DOI:
10.1016/j.psychres.2015.07.041
[Indexed for MEDLINE]

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