Format

Send to

Choose Destination
Gastroenterology. 2015 Oct;149(4):876-882. doi: 10.1053/j.gastro.2015.08.004. Epub 2015 Aug 14.

Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease.

Author information

1
Department of Pathology University of Pittsburgh School of Medicine.
2
Department of Pediatric Gastroenterology University of Pittsburgh School of Medicine.
#
Contributed equally

Abstract

Evidence from human histopathology and experimental studies with rodents and zebrafish has shown that hepatocytes and cholangiocytes may function as facultative stem cells for each other in conditions of impaired regeneration. The interpretation of the findings derived from these studies has generated considerable discussion and some controversies. This review examines the evidence obtained from the different experimental models and considers implications that these studies may have for human liver disease.

KEYWORDS:

Cholangiocytes; Hepatocytes; Liver Progenitor Cell; Liver-Specific Tissue Stem Cells; Transdifferentiation

PMID:
26278502
PMCID:
PMC4584191
DOI:
10.1053/j.gastro.2015.08.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center