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Intern Med. 2015;54(16):2051-5. doi: 10.2169/internalmedicine.54.3570. Epub 2015 Aug 15.

Primary Pleural Synovial Sarcoma Treated with Pazopanib.

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Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan.


A 42-year-old woman presented with chest pain and breathlessness with a nodule measuring 2×2 cm in size at the base of the right lung. A bronchoscopic examination did not reveal any malignancy. However, the patient developed difficulty in breathing, enlargement of the nodule, and right pleural effusion 14 days later. A video-assisted thoracic surgical biopsy specimen revealed the presence of pleural synovial sarcoma. The patient was treated with doxorubicin-ifosfamide combination chemotherapy because of metastasis to the pelvis. However, after a transient partial clinical response, there was a relapse of refractory disease. Although treated with pazopanib as second-line chemotherapy, the patient died eight months after the initial presentation.

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