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Cell. 2015 Aug 13;162(4):708-11. doi: 10.1016/j.cell.2015.07.034.

Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics.

Author information

1
The Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.
2
Genomics and Immunity, NIAMS and NCI, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: rafael.casellas@nih.gov.

Abstract

We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.

PMID:
26276627
PMCID:
PMC4537798
DOI:
10.1016/j.cell.2015.07.034
[Indexed for MEDLINE]
Free PMC Article

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