Format

Send to

Choose Destination
Cell. 2015 Aug 13;162(4):701-3. doi: 10.1016/j.cell.2015.07.050.

An AAA+ ATPase Clamshell Targets Transposition.

Author information

1
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
2
Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA.
3
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jatainer@lbl.gov.

Abstract

DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.

PMID:
26276624
PMCID:
PMC5550827
DOI:
10.1016/j.cell.2015.07.050
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center