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Int J Biol Macromol. 2015 Nov;81:491-7. doi: 10.1016/j.ijbiomac.2015.08.016. Epub 2015 Aug 11.

Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1.

Author information

1
Department of Thyroid & Breast Surgery, The Third Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
2
Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
3
Department of Vascular & Thyroid & Breast Surgery, The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
4
Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
5
Laboratory of Department of Surgery, The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
6
Department of Thyroid & Breast Surgery, The Third Affiliated Hospital of Sun Yet-sen University, Guangzhou, China. Electronic address: wsqiu-d@163.com.

Abstract

MicroRNAs exert their functions by mainly regulating coding genes or long non-coding RNA expression. In the present study, we reported that hsa-miR-1 was down-regulated in breast cancer tissues. Restoration of miR-1 in breast cancer cells inhibited proliferation, motility and increased apoptosis in vitro. MiR-1 functioned as a tumor suppressor by targeting K-RAS and MALAT1. In addition, the effects of up-regulation of miR-1 were similar to that of silencing K-RAS and MALAT1 in breast cancer cells. In vivo study indicated that restoration of miR-1 inhibited tumor growth and metastasis. Patients with low miR-1 expression had poorer overall survival time than those with high miR-1 expression. Our findings emphasized the potential role of miR-1 as tumor suppressive miRNA in breast cancer.

KEYWORDS:

K-RAS; MALAT1; miR-1

PMID:
26275461
DOI:
10.1016/j.ijbiomac.2015.08.016
[Indexed for MEDLINE]

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