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J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):84-9. doi: 10.1093/gerona/glv096. Epub 2015 Aug 13.

Are Performance Measures Necessary to Predict Loss of Independence in Elderly People?

Author information

1
Area di Geriatria, Università Campus Biomedico, Roma, Italy.
2
Area di Geriatria, Università Campus Biomedico, Roma, Italy. l.costanzo@unicampus.it.
3
Institut du Vieillissement. Université de Toulouse, Toulouse, France.
4
Azienda Sanitaria di Firenze, Florence, Italy.
5
National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
6
Area di Geriatria, Università Campus Biomedico, Roma, Italy. Fondazione S. Raffaele, Cittadella della Carità, Taranto, Italy.

Abstract

BACKGROUND:

The frailty phenotype (FP) proposed by Fried and colleagues (Fried LP, Tangen CM, Walston J, et al.; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-M156.) requires the administration of performance tests (gait speed, handgrip strength) not always feasible in routine clinical practice. Furthermore, the discriminative capacity of the instrument has been rarely investigated. Aim of this study was to evaluate the discriminative capacity of the FP and compare it with a modified version including only anamnestic information.

METHODS:

Data are from 890 participants of the InCHIANTI study without impairment in activities of daily living (ADL) at baseline (mean age 74 years, women 55%). Frailty was defined by (a) the presence of ≥ 3 criteria of the FP, and (b) having ≥ 2 criteria of an anamnestic FP (AFP), not including gait speed and handgrip strength. Sensitivity, specificity, positive and negative predictive values (PPV, NPV) were used to evaluate the discriminative capacity of both definitions for incident disability (ie, loss of at least one ADL), incidence of "accelerated" disability (loss of >2 ADL) over a 6-year follow-up, and 5-years mortality.

RESULTS:

FP and AFP yielded a frailty prevalence of 6.4% and 6.5%, respectively; only 32 patients were considered frail by both indices (kappa: .53). For incident disability, FP showed sensitivity = .194, specificity = .963, PPV = .400, and NPV = .903. Similarly, AFP had sensitivity = .129, specificity = .949, PPV = .245, and NPV = .894. Consistent results were found for accelerated disability and mortality.

CONCLUSIONS:

In our sample, both FP and AFP showed low sensitivity in identifying older people who would die or develop disability, but they could well discriminate people who would not experience adverse outcomes.

KEYWORDS:

Disability; Frailty; Mortality; Predictive value; Sensitivity and specificity.

PMID:
26273019
PMCID:
PMC4715230
DOI:
10.1093/gerona/glv096
[Indexed for MEDLINE]
Free PMC Article

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