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Nat Rev Microbiol. 2015 Sep;13(9):529-43. doi: 10.1038/nrmicro3521.

Staphylococcal manipulation of host immune responses.

Author information

1
1] Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA. [2] Regeneron Pharmaceuticals, 755 Old Saw Mill River Road, Tarrytown, New York 10591, USA.
2
Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.

Abstract

Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and modify host B cell and T cell responses, and we discuss how these insights might be useful for the development of novel therapies against infections with antibiotic resistant strains such as methicillin-resistant S. aureus.

PMID:
26272408
PMCID:
PMC4625792
DOI:
10.1038/nrmicro3521
[Indexed for MEDLINE]
Free PMC Article

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