Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2015 Oct 1;25(19):4325-8. doi: 10.1016/j.bmcl.2015.07.067. Epub 2015 Jul 26.

Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp.

Author information

1
Department of Applied Biological Science, Tokyo University of Sciences, Noda, Chiba 278-8510, Japan.
2
Department of Applied Biological Science, Tokyo University of Sciences, Noda, Chiba 278-8510, Japan; Department of Virology II, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
3
Department of Applied Biological Science, Tokyo University of Sciences, Noda, Chiba 278-8510, Japan. Electronic address: sugawara@rs.noda.tus.ac.jp.

Abstract

Two new tricyclic polyketides, vanitaracin A (1) and B (2), together with three novel compounds 3, 4 and 5, were isolated from a culture broth of a fungus, Talaromyces sp. The chemical structures of these compounds were determined from spectroscopic data (1D/2D NMR, MS and IR). The five isolated compounds were then tested for anti-hepatitis B virus (HBV) activity and vanitaracin A was found to exhibit an IC50 value of 10.5 μM using a HBV-susceptible cell line. By contrast, the derivative 2 displayed weak anti-HBV action, which suggested that the substituents at C-9 in 1 are likely to be important for its antiviral activity. We believe the two vanitaracin derivatives constitute a new class of anti-HBV agents.

KEYWORDS:

HBV; Infection; Natural products; Structure determination

PMID:
26271586
DOI:
10.1016/j.bmcl.2015.07.067
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center