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Trends Mol Med. 2015 Sep;21(9):571-9. doi: 10.1016/j.molmed.2015.07.003. Epub 2015 Aug 10.

Regulation of brown fat by AMP-activated protein kinase.

Author information

1
Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, post zone C7Q, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address: a.d.van_dam@lumc.nl.
2
Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, post zone C7Q, PO Box 9600, 2300 RC Leiden, The Netherlands.

Abstract

Novel strategies are needed to reduce the obesity epidemic. One promising strategy is activation of brown adipose tissue (BAT), either via the brain or directly, which increases energy expenditure by combustion of fatty acids (FAs) into heat. The enzyme complex AMP-activated protein kinase (AMPK) is crucially involved in energy metabolism and is highly expressed in both brain and BAT, regulating thermogenesis. As a general rule, BAT activity and energy expenditure are increased either by suppression of AMPK activity in the brain, resulting in enhanced sympathetic outflow towards BAT, or by activation of AMPK in BAT. Targeting AMPK may thus hold therapeutic potential for the treatment of obesity and related disorders.

KEYWORDS:

AMP-activated protein kinase; brown adipose tissue; energy expenditure; hypothalamus; thermogenesis; uncoupling protein 1

PMID:
26271143
DOI:
10.1016/j.molmed.2015.07.003
[Indexed for MEDLINE]

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