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Int J Rheum Dis. 2016 Jan;19(1):49-54. doi: 10.1111/1756-185X.12727. Epub 2015 Aug 13.

Dry eye in vitamin D deficiency: more than an incidental association.

Author information

1
Department of Physical Medicine and Rehabilitation, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.
2
Department of Physical Medicine and Rehabilitation, Basak Medical Center, Ankara, Turkey.
3
Department of Ophtalmology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Abstract

AIM:

The aim of this article is two-fold: (i) to demonstrate the relation between vitamin D deficiency and dry eye and impaired tear function; and (ii) to investigate the possible associations among clinical parameters of hypovitaminosis D with dry eye parameters.

METHOD:

Fifty premenopausal women with vitamin D deficiency (serum vitamin D levels < 20 ng/mL) and 48 controls were included. Participants were assessed by Schirmer's test, tear break-up time test (TBUT), ocular surface disease index (OSDI), Stanford Health Assessment Questionnaire (HAQ), fatigue severity scale (FSS), and visual analogue scale-pain (VAS-pain).

RESULTS:

Lower scores in Schirmer's test and TBUT, and higher in OSDI were detected in patients with vitamin D deficiency than in controls (P < 0.05). FSS was negatively correlated with Schirmer's test (r = -0,29; P = 0.038) and TBUT scores (r = -0,43; P = 0.002); VAS-pain was negatively correlated with TBUT scores (r = -0.32; P = 0.023). HAQ scores showed no significant correlation with dry eye parameters (P > 0.05). Vitamin D level was negatively correlated with OSDI (r = -0.49; P < 0.001), and positively with Schirmer's test (r = 0.45; P = 0.001) and TBUT scores (r = 0.30; P = 0.029).

CONCLUSION:

Dry eye and impaired tear function in patients with vitamin D deficiency may indicate a protective role of vitamin D in the development of dry eye, probably by enhancing tear film parameters and reducing ocular surface inflammation. Patients with vitamin D deficiency should be evaluated for dry eye syndromes.

KEYWORDS:

dry eye syndromes; fatigue; pain; quality of life; vitamin D deficiency

PMID:
26269110
DOI:
10.1111/1756-185X.12727
[Indexed for MEDLINE]

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