Format

Send to

Choose Destination
Ann Pharmacother. 2015 Nov;49(11):1207-13. doi: 10.1177/1060028015600176. Epub 2015 Aug 12.

Acute Kidney Injury With Tobramycin-Impregnated Bone Cement Spacers in Prosthetic Joint Infections.

Author information

1
Surrey Memorial Hospital, Surrey, BC, Canada.
2
Vancouver General Hospital, Vancouver, BC, Canada karen.shalansky@vch.ca.
3
Vancouver General Hospital, Vancouver, BC, Canada.

Abstract

BACKGROUND:

Antibiotic-impregnated bone cement spacer (ACS) with tobramycin ± vancomycin is commonly used in a 2-stage replacement of infected prosthetic joints. This procedure has been associated with development of acute kidney injury (AKI).

OBJECTIVE:

To determine the incidence and risk factors for AKI after implantation of tobramycin-impregnated ACS.

METHODS:

This prospective, observational study evaluated 50 consecutive patients who received tobramycin ACS for first-stage revision of an infected hip or knee arthroplasty from August 2011 to February 2013. AKI was defined as 50% or greater rise in serum creatinine (SCr) from baseline within the first 7 postoperative days (PODs).

RESULTS:

The incidence of AKI was 20%, with median onset occurring at POD 2 (interquartile range [IQR] = 1-3); patients with AKI had a longer median duration of hospital stay (16 days, IQR = 12-17, vs 10 days, IQR = 8-10; P = 0.03). Serum tobramycin concentrations were significantly higher in the AKI group, peaking on POD 1 (median 1.9 vs 0.9 µg/mL, P = 0.01). Risk factors for nephrotoxicity identified by multivariate analysis were use of bone cement premanufactured with gentamicin (OR = 8.2; 95% CI = 1.1-60; P = 0.04), administration of blood transfusions intraoperatively (OR = 32.5; 95% CI = 2.3-454.3; P = 0.01) and nonsteroidal anti-inflammatory drugs postoperatively (OR = 23.0; 95% CI = 1.3-397.7; P = 0.03).

CONCLUSIONS:

Tobramycin ACS is associated with a high risk of AKI. Measures to minimize AKI risk in the perioperative period include early detection through close monitoring of SCr, avoiding use of premanufactured bone cement containing gentamicin, and avoiding potential nephrotoxins within the first 72 hours postoperatively.

KEYWORDS:

aminoglycosides; bone/joint disorders; drug delivery; infectious diseases; nephrotoxicity; orthopedics; surgery; vancomycin

PMID:
26269097
DOI:
10.1177/1060028015600176
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center