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ACS Appl Mater Interfaces. 2015 Sep 2;7(34):19466-73. doi: 10.1021/acsami.5b05865. Epub 2015 Aug 20.

Facile Fabrication of Lubricant-Infused Wrinkling Surface for Preventing Thrombus Formation and Infection.

Yuan S1,2, Luan S1, Yan S1,2, Shi H1, Yin J1.

Author information

1
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
2
University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.

Abstract

Despite the advanced modern biotechniques, thrombosis and bacterial infection of biomedical devices remain common complications that are associated with morbidity and mortality. Most antifouling surfaces are in solid form and cannot simultaneously fulfill the requirements for antithrombosis and antibacterial efficacy. In this work, we present a facile strategy to fabricate a slippery surface. This surface is created by combining photografting polymerization with osmotically driven wrinkling that can generate a coarse morphology, and followed by infusing with fluorocarbon liquid. The lubricant-infused wrinkling slippery surface can greatly prevent protein attachment, reduce platelet adhesion, and suppress thrombus formation in vitro. Furthermore, E. coli and S. aureus attachment on the slippery surfaces is reduced by ∼98.8% and ∼96.9% after 24 h incubation, relative to poly(styrene-b-isobutylene-b-styrene) (SIBS) references. This slippery surface is biocompatible and has no toxicity to L929 cells. This surface-coating strategy that effectively reduces thrombosis and the incidence of infection will greatly decrease healthcare costs.

KEYWORDS:

antibacterial; antifouling; photografting polymerization; poly(styrene-b-isobutylene-b-styrene) (SIBS); slippery surface

PMID:
26268298
DOI:
10.1021/acsami.5b05865
[Indexed for MEDLINE]

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