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Cancer Cell. 2015 Aug 10;28(2):149-50. doi: 10.1016/j.ccell.2015.07.011.

Tumor Heterogeneity: Focus on the Leaves, the Trees, or the Forest?

Author information

1
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
2
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: cperou@med.unc.edu.

Abstract

Molecular studies of intra-tumor heterogeneity (ITH) are revealing a large amount of DNA-based variation in many individual tumors. In a recent publication by Yates and colleagues, the ITH of breast tumors was examined and shown to have important implications for the development of resistant disease, metastasis, and clinical sequencing efforts.

PMID:
26267531
DOI:
10.1016/j.ccell.2015.07.011
[Indexed for MEDLINE]
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