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Cancer Cell. 2015 Aug 10;28(2):143-5. doi: 10.1016/j.ccell.2015.07.010.

PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?

Author information

1
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA. Electronic address: atoker@bidmc.harvard.edu.
2
Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118, USA. Electronic address: rameh@bu.edu.

Abstract

In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.

PMID:
26267528
DOI:
10.1016/j.ccell.2015.07.010
[Indexed for MEDLINE]
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