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Dev Cell. 2015 Aug 10;34(3):255-65. doi: 10.1016/j.devcel.2015.07.012.

Organ Size Control: Lessons from Drosophila.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: ikh@berkeley.edu.

Abstract

Of fundamental interest to biologists is how organs achieve a reproducible size during development. Studies of the developing Drosophila wing have provided many key insights that will help give a conceptual understanding of the process beyond the fly. In the wing, there is evidence for both "top-down" mechanisms, in which signals emanating from small subsets of cells direct global proliferation, and "bottom-up" mechanisms, in which the final size is an emergent property of local cell-cell interactions. Mechanical forces also appear to have an important role along with the Hippo pathway, which may integrate multiple types of inputs to regulate the extent of growth.

PMID:
26267393
PMCID:
PMC4547687
DOI:
10.1016/j.devcel.2015.07.012
[Indexed for MEDLINE]
Free PMC Article

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