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J Biophotonics. 2016 Jul;9(7):760-9. doi: 10.1002/jbio.201580156. Epub 2015 Aug 12.

Optical detection of glucose and glycated hemoglobin using etched fiber Bragg gratings coated with functionalized reduced graphene oxide.

Author information

1
Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore, 560012, India.
2
Department of Physics, Indian Institute of Science, Bangalore, 560012, India.
3
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India.
4
Robert Bosch Centre for Cyber Physical Systems, Indian Institute of Science, Bangalore, 560012, India.
5
Department of Physics, Indian Institute of Science, Bangalore, 560012, India. asood1951@gmail.com.

Abstract

An enhanced optical detection of D-glucose and glycated hemoglobin (HbA1c ) has been established in this study using etched fiber Bragg gratings (eFBG) coated with aminophenylboronic acid (APBA)-functionalized reduced graphene oxide (RGO). The read out, namely the shift in Bragg wavelength (ΔλB ) is highly sensitive to changes that occur due to the adsorption of glucose (or HbA1c ) molecules on the eFBG sensor coated with APBA-RGO complex through a five-membered cyclic ester bond formation between glucose and APBA molecules. A limit of detection of 1 nM is achieved with a linear range of detection from 1 nM to 10 mM in the case of D-glucose detection experiments. For HbA1c , a linear range of detection varying from 86 nM to 0.23 mM is achieved. The observation of only 4 pm (picometer) change in ΔλB even for the 10 mM lactose solution confirms the specificity of the APBA-RGO complex coated eFBG sensors to glucose molecules.

KEYWORDS:

Fiber Bragg grating; HbA1c; aminophenylboronic acid; glucose; reduced graphene oxide

PMID:
26266873
DOI:
10.1002/jbio.201580156
[Indexed for MEDLINE]

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