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Int J Geriatr Psychiatry. 2016 Apr;31(4):400-5. doi: 10.1002/gps.4345. Epub 2015 Aug 12.

Obstructive sleep apnoea and dementia: is there a link?

Author information

1
Dorset HealthCare University NHS Foundation Trust, Poole, UK.
2
Leeds and York Partnership NHS Foundation Trust, Leeds, UK.
3
Leeds Institute of Medical Education, School of Medicine, University of Leeds, Leeds, UK.

Abstract

OBJECTIVE:

Obstructive sleep apnoea is a common sleep disturbance in people of all ages, while dementia is an increasing entity among the ageing population of the world. Recent studies have established a link between sleep apnoea and cognitive decline. This literature review explores this relationship and examines the mechanisms, neurobiology and treatment modalities.

DESIGN:

The study was conducted with the use of narrative literature overview.

RESULTS AND CONCLUSIONS:

While there are numerous studies that establish a clear relationship between obstructive sleep apnoea, cognitive decline and dementia, more work is needed in understanding the mechanism and processes involved. A detailed understanding of pathophysiology of sleep and the relationship with cognitive decline will be vital in addressing the possibility of averting a likely reversible cause of dementia or cognitive decline.

KEYWORDS:

cognition; dementia; sleep apnoea

PMID:
26266479
DOI:
10.1002/gps.4345
[Indexed for MEDLINE]

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