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Chemother Res Pract. 2015;2015:639806. doi: 10.1155/2015/639806. Epub 2015 Jul 22.

Aloe vera Gel: Effective Therapeutic Agent against Multidrug-Resistant Pseudomonas aeruginosa Isolates Recovered from Burn Wound Infections.

Author information

1
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Science, Tehran 1985717443, Iran.
2
WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran 1316943551, Iran.
3
Department of Medical Laboratory Sciences, School of Paramedicine, Qazvin University of Medical Sciences, Qazvin 1651135779, Iran.
4
Department of Medical Mycology, Pasteur Institute of Iran, Tehran 1316943551, Iran.
5
Department of Medical Laboratory Sciences, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.

Abstract

OBJECTIVE:

Aloe vera is an herbal medicinal plant with biological activities, such as antimicrobial, anticancer, anti-inflammatory, and antidiabetic ones, and immunomodulatory properties. The purpose of this study was investigation of in vitro antimicrobial activity of A. vera gel against multidrug-resistant (MDR) Pseudomonas aeruginosa isolated from patients with burn wound infections.

METHODS:

During a 6-month study, 140 clinical isolates of P. aeruginosa were collected from patients admitted to the burn wards of a hospital in Tehran, Iran. Antimicrobial susceptibility test was carried out against the pathogens using the A. vera gel and antibiotics (imipenem, gentamicin, and ciprofloxacin).

RESULTS:

The antibiogram revealed that 47 (33.6%) of all isolates were MDR P. aeruginosa. The extract isolated from A. vera has antibacterial activity against all of isolates. Also, 42 (89.4%) isolates were inhibited by A. vera gel extract at minimum inhibitory concentration (MIC) ≤ 200 µg/mL. MIC value of A. vera gel for other isolates (10.6%) was 800 µg/mL. All of MDR P. aeruginosa strains were inhibited by A. vera at similar MIC50 and MIC90 200 µg/mL.

CONCLUSION:

Based on our results, A. vera gel at various concentrations can be used as an effective antibacterial agent in order to prevent wound infection caused by P. aeruginosa.

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