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BMC Cancer. 2015 Aug 12;15:582. doi: 10.1186/s12885-015-1574-5.

LC3B globular structures correlate with survival in esophageal adenocarcinoma.

Author information

1
Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College, Cork, Ireland.
2
Department of Pathology, Royal College of Surgeons Ireland (RCSI), Beaumont Hospital, Dublin, Ireland.
3
National Liver Institute, Menoufiya University, Shebin El Kom, Egypt.
4
Department of Surgery & Trinity Centre for Health Sciences, St James Hospital, Dublin, Ireland.
5
Department of Oncology, Cork University Hospital, Cork, Ireland.
6
Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College, Cork, Ireland. s.mckenna@ucc.ie.

Abstract

BACKGROUND:

Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome.

METHODS:

Esophageal adenocarcinoma tumor tissue from two independent sites, was examined retrospectively. Tumors from 104 neoadjuvant naïve patients and 48 patients post neoadjuvant therapy were assembled into tissue microarrays prior to immunohistochemical analysis. Kaplan-Meier survival curves and log-rank tests were used to assess impact of LC3B expression on survival. Cox regression was used to examine association with clinical risk factors.

RESULTS:

A distinct globular pattern of LC3B expression was found to be predictive of outcome in both patient groups, irrespective of treatment (p < 0.001). Multivariate analysis found that this was a strong independent predictor of poor prognosis (p < 0.001).

CONCLUSIONS:

This distinctive staining pattern of LC3B represents a novel prognostic marker for resectable esophageal adenocarcinoma.

PMID:
26265176
PMCID:
PMC4533787
DOI:
10.1186/s12885-015-1574-5
[Indexed for MEDLINE]
Free PMC Article

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