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Tissue Antigens. 2015 Sep;86(3):199-204. doi: 10.1111/tan.12637.

HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand.

Author information

1
Department of Blood Bank, Faculty of Medical Technology, Huachiew Chalermprakiet University, Samut Prakarn, Thailand.
2
Department of Clinical Immunology and Transfusion Sciences, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
3
The Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
4
Blood Transfusion Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
5
Centre for Forensic Science, The University of Western Australia, Nedlands, Australia.
6
Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Tokyo, Japan.
7
Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia.

Abstract

This is the first report on human leukocyte antigen (HLA) allele and haplotype frequencies at three class I loci and two class II loci in unrelated healthy individuals from two ethnic groups, 170 Burmese and 200 Karen, originally from Burma (Myanmar), but sampled while residing in Thailand. Overall, the HLA allele and haplotype frequencies detected by polymerase chain reaction sequence-specific primer (PCR-SSP) at five loci (A, B, C, DRB1 and DRQB1) at low resolution showed distinct differences between the Burmese and Karen. In Burmese, five HLA-B*15 haplotypes with different HLA-A and HLA-DR/DQ combinations were detected with three of these not previously reported in other Asian populations. The data are important in the fields of anthropology, transplantation and disease-association studies.

KEYWORDS:

Burmese; Karen; Southeast Asian; haplotype frequency; human leukocyte antigen

PMID:
26265055
DOI:
10.1111/tan.12637
[Indexed for MEDLINE]

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