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Chem Commun (Camb). 2015 Sep 28;51(75):14171-14174. doi: 10.1039/c5cc04727g. Epub 2015 Aug 12.

Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells.

Author information

1
University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering, 206 Roger Adams Lab, Box C-3, MC-712, 600 South Methews Avenue, Urbana, IL 61801 (USA).
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Contributed equally

Abstract

Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% cell death. The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.

PMID:
26264283
PMCID:
PMC4560650
DOI:
10.1039/c5cc04727g
[Indexed for MEDLINE]
Free PMC Article

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