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Brain Struct Funct. 2016 Jul;221(6):3193-209. doi: 10.1007/s00429-015-1095-7. Epub 2015 Aug 12.

Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse.

Author information

1
Department of Neuroscience, Neuroscience Institute of Turin (NIT), University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
2
Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
3
Department of Surgical Sciences, University of Turin, Via Genova 3, 10126, Turin, Italy.
4
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
5
Department of Neuroscience, Neuroscience Institute of Turin (NIT), University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy. daniela.carulli@unito.it.
6
Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy. daniela.carulli@unito.it.

Abstract

Perineuronal nets (PNNs) are aggregates of extracellular matrix molecules surrounding several types of neurons in the adult CNS, which contribute to stabilising neuronal connections. Interestingly, a reduction of PNN number and staining intensity has been observed in conditions associated with plasticity in the adult brain. However, it is not known whether spontaneous PNN changes are functional to plasticity and repair after injury. To address this issue, we investigated PNN expression in the vestibular nuclei of the adult mouse during vestibular compensation, namely the resolution of motor deficits resulting from a unilateral peripheral vestibular lesion. After unilateral labyrinthectomy, we found that PNN number and staining intensity were strongly attenuated in the lateral vestibular nucleus on both sides, in parallel with remodelling of excitatory and inhibitory afferents. Moreover, PNNs were completely restored when vestibular deficits of the mice were abated. Interestingly, in mice with genetically reduced PNNs, vestibular compensation was accelerated. Overall, these results strongly suggest that temporal tuning of PNN expression may be crucial for vestibular compensation.

KEYWORDS:

Axonal plasticity; Bral2; Chondroitin sulphate proteoglycans; Perineuronal nets; Vestibular compensation; Vestibular nuclei

PMID:
26264050
DOI:
10.1007/s00429-015-1095-7
[Indexed for MEDLINE]

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