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Nat Commun. 2015 Aug 11;6:7934. doi: 10.1038/ncomms8934.

Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study.

Author information

1
Orygen-The National Centre of Excellence in Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Victoria 3052, Australia.
2
Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna 1090, Austria.
3
Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna 1090, Austria.

Abstract

Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue, omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia. We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo. We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years. Here we show that brief intervention with omega-3 PUFAs reduced both the risk of progression to psychotic disorder and psychiatric morbidity in general in this study. The majority of the individuals from the omega-3 group did not show severe functional impairment and no longer experienced attenuated psychotic symptoms at follow-up.

PMID:
26263244
PMCID:
PMC4918317
DOI:
10.1038/ncomms8934
[Indexed for MEDLINE]
Free PMC Article

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