Send to

Choose Destination
Redox Biol. 2015 Dec;6:198-205. doi: 10.1016/j.redox.2015.07.012. Epub 2015 Jul 29.

Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study.

Author information

Centre d'Enseignement et de Recherche en Nutrition Humaine, Centre Hospitalier de Bretagne Sud, 5 Avenue De Choiseul, BP 12233, 56322 Lorient Cedex, France. Electronic address:
Laboratoires Le Stum, 4 impasse de Kerhoas, 56260 Larmor Plage, France. Electronic address:
Unité de Biochimie Hormonale et Nutritionnelle, Département de Biochimie, Toxicologie et Pharmacologie, Institut de Biologie et de Pathologie, Centre Hospitalier Universitaire de Grenoble, CS10217, 38043 Grenoble, France. Electronic address:
Laboratoires Le Stum, 4 impasse de Kerhoas, 56260 Larmor Plage, France. Electronic address:


Glutathione (GSH) is critical to fight against oxidative stress. Its very low bioavailability limits the interest of a supplementation. The purpose of this study was to compare the bioavailability, the effect on oxidative stress markers and the safety of a new sublingual form of GSH with two commonly used dietary supplements, N-acetylcysteine (NAC) and oral GSH. The study was a three-week randomized crossover trial. 20 Volunteers with metabolic syndrome were enrolled. GSH levels and several oxidative stress markers were determined at different times during each 21-days period. Compared to oral GSH group, an increase of total and reduced GSH levels in plasma and a higher GSH/GSSG ratio (p=0.003) was observed in sublingual GSH group. After 3 weeks of administration, there was a significant increase of vitamin E level in plasma only in sublingual GSH group (0.83 µmol/g; p=0.04). Our results demonstrate the superiority of a new sublingual form of GSH over the oral GSH form and NAC in terms of GSH supplementation.


Dietary supplement; Glutathione; Metabolic syndrome; N-acetyl cysteine; Nutraceuticals; Oral bioavailability; Oxidative stress; Sublingual

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center