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Int J Mol Sci. 2015 Aug 7;16(8):18454-73. doi: 10.3390/ijms160818454.

Novel Electrocardiographic Patterns for the Prediction of Hypertensive Disorders of Pregnancy--From Pathophysiology to Practical Implications.

Author information

1
Division of Cardiology and Cardiovascular Pathophysiology, Hospital "S.M. della Misericordia", Perugia 06100, Italy. angeli.internet@gmail.com.
2
Department of Obstetrics and Gynecology, Hospital "San Giovanni Battista", Foligno 06034, Italy. angeli.enrica@gmail.com.
3
Department of Internal medicine, Hospital of Assisi, Assisi 06081, Italy. verdec@tin.it.

Abstract

Hypertensive disorders of pregnancy are a major cause of poor outcome, including placental abruption, organ failure, cerebrovascular accident and disseminated intravascular coagulation. These disorders are associated with increased fetal risk of intrauterine growth restriction, intrauterine death and prematurity. Electrocardiography (ECG) recently emerged as a useful tool to evaluate cardiovascular complications during pregnancy. Specifically, left atrial abnormalities detected by standard ECG are associated with a fourfold increased risk of developing hypertensive disorders during pregnancy. The mechanisms linking left atrial abnormality on ECG with hypertensive disorders are still elusive. Several mechanisms, possibly reflected by abnormal left atrial activation on ECG, has been suggested. These include increased reactivity to angiotensin II and up-regulation of angiotensin type 1 receptors, with activation of autoantibodies targeting these receptors.

KEYWORDS:

blood pressure; eclampsia; electrocardiography; high-risk; hypertension; pre-eclampsia; pregnancy; pregnancy-induced

PMID:
26262614
PMCID:
PMC4581255
DOI:
10.3390/ijms160818454
[Indexed for MEDLINE]
Free PMC Article

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