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Int J Clin Exp Pathol. 2015 Jun 1;8(6):6466-73. eCollection 2015.

Effects of dexmedetomidine on the protection of hyperoxia-induced lung injury in newborn rats.

Author information

1
Department of Paediatrics, The First Affiliated Hospital of Harbin Medical University Harbin 150001, People's Republic of China.
2
Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University Harbin 150001, People's Republic of China.

Abstract

Dexmedetomidine (Dex) is a specific agonist of α2-adrenoceptor and was reported to have protective effect on a variety of organs, however the effect of Dex on hyperoxia-induced lung injury remains unknown. In the present study, Dex was administrated to newborn rats and its effect against hyperoxia-induced lung injury was examined. The results showed that, Dex significantly attenuated the aberration, macrophage infiltration, inflammatory responses and pulmonary edema induced by hyperoxia. In addition, the down-regulation of AQP1 was also reversed by Dex. These data indicate that Dex may be a potential therapy in the prevention of hyperoxia-induced lung injury in infants.

KEYWORDS:

AQP1; Dexmedetomidine; hyperoxia-induced lung injury; inflammatory responses; pulmonary edema

PMID:
26261523
PMCID:
PMC4525857
[Indexed for MEDLINE]
Free PMC Article

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