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Cold Spring Harb Perspect Biol. 2015 Aug 10;8(3):a019232. doi: 10.1101/cshperspect.a019232.

Mechanical Forces and Growth in Animal Tissues.

Author information

1
National Center for Scientific Research, Developmental Biology Institute of Marseille-Luminy, Aix Marseille Université, 13009 Marseille, France.

Abstract

Mechanical forces shape biological tissues. They are the effectors of the developmental programs that orchestrate morphogenesis. A lot of effort has been devoted to understanding morphogenetic processes in mechanical terms. In this review, we focus on the interplay between tissue mechanics and growth. We first describe how tissue mechanics affects growth, by influencing the orientation of cell divisions and the signaling pathways that control the rate of volume increase and proliferation. We then address how the mechanical state of a tissue is affected by the patterns of growth. The forward and reverse interactions between growth and mechanics must be investigated in an integrative way if we want to understand how tissues grow and shape themselves. To illustrate this point, we describe examples in which growth homeostasis is achieved by feedback mechanisms that use mechanical forces.

PMID:
26261279
PMCID:
PMC4772101
DOI:
10.1101/cshperspect.a019232
[Indexed for MEDLINE]
Free PMC Article

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