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J Exp Med. 2015 Aug 24;212(9):1345-60. doi: 10.1084/jem.20151159. Epub 2015 Aug 10.

T cell metabolism drives immunity.

Author information

1
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
2
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 pearce@ie-freiburg.mpg.de.

Abstract

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal development, during which they undergo a dramatic metabolic remodeling process. Research in this area has yielded surprising findings on the roles of diverse metabolic pathways and metabolites, which have been found to regulate lymphocyte signaling and influence differentiation, function and fate. In this review, we integrate the latest findings in the field to provide an up-to-date resource on lymphocyte metabolism.

PMID:
26261266
PMCID:
PMC4548052
DOI:
10.1084/jem.20151159
[Indexed for MEDLINE]
Free PMC Article

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