Format

Send to

Choose Destination
Nat Rev Genet. 2015 Sep;16(9):517-29. doi: 10.1038/nrg3963. Epub 2015 Aug 11.

Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning.

Author information

1
School of Biochemistry and Cell Biology, University College Cork, Ireland.
2
1] School of Biochemistry and Cell Biology, University College Cork, Ireland. [2] Department of Human Genetics, University of Utah, 15 N 2030 E Rm. 7410, Salt Lake City, Utah 84112-5330, USA.

Abstract

The non-universality of the genetic code is now widely appreciated. Codes differ between organisms, and certain genes are known to alter the decoding rules in a site-specific manner. Recently discovered examples of decoding plasticity are particularly spectacular. These examples include organisms and organelles with disruptions of triplet continuity during the translation of many genes, viruses that alter the entire genetic code of their hosts and organisms that adjust their genetic code in response to changing environments. In this Review, we outline various modes of alternative genetic decoding and expand existing terminology to accommodate recently discovered manifestations of this seemingly sophisticated phenomenon.

PMID:
26260261
DOI:
10.1038/nrg3963
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center