Format

Send to

Choose Destination
Antiviral Res. 2015 Oct;122:55-63. doi: 10.1016/j.antiviral.2015.08.002. Epub 2015 Aug 8.

Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1.

Author information

1
Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 4, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina; Departamento de Química Orgánica and UMYMFOR (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.
2
Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 4, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.
3
Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Piso 4, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.
4
Departamento de Química Orgánica and UMYMFOR (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina. Electronic address: jar@qo.fcen.uba.ar.

Abstract

The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant viral strains, principally when immunosuppressed patients are involved. Thus, the development of new antiherpetic compounds remains as a central challenge. In this work we describe the synthesis and the in vitro antiherpetic activity of a new family of steroidal compounds derived from the endogenous hormone pregnenolone. Some of these derivatives showed a remarkable inhibitory effect on HSV-1 spread both on wild type and ACV-resistant strains. The results also show that these compounds seem to interfere with the late steps of the viral cycle.

KEYWORDS:

Acyclovir resistant; Antiviral; Herpes simplex type I; Non-natural side chains; Pregnenolone analogs

PMID:
26259812
DOI:
10.1016/j.antiviral.2015.08.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center