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Iran J Public Health. 2015 Jun;44(6):797-803.

Does Supplementation with Royal Jelly Improve Oxidative Stress and Insulin Resistance in Type 2 Diabetic Patients?

Author information

1
Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran.
2
Dept. of Cellular & Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran.
3
Research Center for Endocrinology and Metabolism, Institute of Endocrinology in Firouzgar Hospital, Iran University of Medical Sciences, Iran.
4
Dept. of Statistics, School of Health Management and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Animal studies have shown antioxidant effects of Royal Jelly (RJ) and its effect on insulin resistance as the most common complication of Type 2 diabetes. This study was conducted to determine the effect of RJ intake on serum total antioxidant capacity, Malondialdehyde and insulin resistance in T2DM.

METHODS:

In this randomized controlled trial, forty-six type 2 diabetic patients, aged 25-65 years, with BMI of 20-30 kg/m(2), and HbA1c of 6-8% were included. The patients were randomly assigned to receive 1000 mg of RJ supplement or placebo, 3 times daily for 8 weeks. HOMA-IR, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured.

RESULTS:

In comparison with placebo, HOMA-IR decreased (P=0.015) while serum total antioxidant capacity increased significantly in RJ group (P=0.016). No significant difference was detected for serum insulin and MDA in two groups.

CONCLUSIONS:

RJ intake may have favorable effects on serum TAC and HOMA-IR in diabetic patients.

KEYWORDS:

Insulin resistance; Royal Jelly; Total antioxidant capacity; Type 2 diabetes mellitus

PMID:
26258092
PMCID:
PMC4524304

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