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J Adv Res. 2015 May;6(3):383-92. doi: 10.1016/j.jare.2015.02.003. Epub 2015 Feb 24.

Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review.

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Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.


Pharmacokinetic drug-drug interactions (in particular at metabolism) may result in fatal adverse effects in some cases. This basic information, therefore, is needed for drug therapy even in veterinary medicine, as multidrug therapy is not rare in canines and felines. The aim of this review was focused on possible drug-drug interactions in dogs and cats. The interaction includes enzyme induction by phenobarbital, enzyme inhibition by ketoconazole and fluoroquinolones, and down-regulation of enzymes by dexamethasone. A final conclusion based upon the available literatures and author's experience is given at the end of the review.


Cats; Dogs; Drug metabolism; Drug–drug interaction; Pharmacokinetics

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