Getting the genome in shape: the formation of loops, domains and compartments

Britta A M Bouwman; Wouter de Laat

doi:10.1186/s13059-015-0730-1

Getting the genome in shape: the formation of loops, domains and compartments

Genome Biol. 2015 Aug 10;16(1):154. doi: 10.1186/s13059-015-0730-1.

Authors

Britta A M Bouwman¹, Wouter de Laat²

Affiliations

¹ Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
² Hubrecht Institute - KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands. w.delaat@hubrecht.eu.

Abstract

The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chromatin / chemistry*
Enhancer Elements, Genetic
Gene Expression Regulation
Genome*
Promoter Regions, Genetic
Transcription Factors / metabolism
Transcription, Genetic*

Substances

Chromatin
Transcription Factors