Format

Send to

Choose Destination
Neuron. 2015 Aug 19;87(4):893-905. doi: 10.1016/j.neuron.2015.07.013. Epub 2015 Aug 6.

Parietal and Frontal Cortex Encode Stimulus-Specific Mnemonic Representations during Visual Working Memory.

Author information

1
Department of Psychology, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address: eester@ucsd.edu.
2
Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA, 92093, USA.
3
Department of Psychology, University of California, San Diego, La Jolla, CA, 92093, USA; Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address: jserences@ucsd.edu.

Abstract

Working memory (WM) enables the storage and manipulation of information in an active state. WM storage has long been associated with sustained increases in activation across a network of frontal and parietal cortical regions. However, recent evidence suggests that these regions primarily encode information related to general task goals rather than feature-selective representations of specific memoranda. These goal-related representations are thought to provide top-down feedback that coordinates the representation of fine-grained details in early sensory areas. Here, we test this model using fMRI-based reconstructions of remembered visual details from region-level activation patterns. We could reconstruct high-fidelity representations of a remembered orientation based on activation patterns in occipital visual cortex and in several sub-regions of frontal and parietal cortex, independent of sustained increases in mean activation. These results challenge models of WM that postulate disjoint frontoparietal "top-down control" and posterior sensory "feature storage" networks.

PMID:
26257053
PMCID:
PMC4545683
DOI:
10.1016/j.neuron.2015.07.013
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center