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Anaerobe. 2015 Dec;36:88-90. doi: 10.1016/j.anaerobe.2015.07.009. Epub 2015 Aug 6.

Antibiotic profiling of Clostridium difficile ribotype 176--A multidrug resistant relative to C. difficile ribotype 027.

Author information

1
Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic; DNA laboratory, Department of Paediatric Neurology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic. Electronic address: marcela.krutova@seznam.cz.
2
Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, Czech Republic.

Abstract

Antibiotic profiling of twenty Czech Clostridium difficile PCR-ribotype 176 isolates revealed a high level of resistance to erythromycin, ciprofloxacin and moxifloxacin (n = 20) and to rifampicin (n = 13). Accumulation of resistance mechanisms to multiple antibiotics highlight that PCR-ribotype 176 belong to problematic epidemic strains.

KEYWORDS:

Clostridium difficile; Erythromycin; Moxifloxacin; PCR-ribotype 176; Resistance; Rifampicin; Thr82Ile

PMID:
26256807
DOI:
10.1016/j.anaerobe.2015.07.009
[Indexed for MEDLINE]

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