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Mol Nutr Food Res. 2015 Nov;59(11):2326-36. doi: 10.1002/mnfr.201500290. Epub 2015 Sep 2.

Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats.

Author information

1
Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Granada, Spain.
2
Instituto de Investigación Biosanitaria de Granada (ibs. GRANADA), Granada, Spain.
3
Laboratorio de Descubrimiento y Preclínica, Departamento de Investigación BIOSEARCH S.A, Granada, Spain.
4
CIBER-ehd, Departamento de Farmacología, CIBM, Universidad de Granada, Armilla (Granada), Spain.

Abstract

SCOPE:

The cardiovascular effects of probiotics Lactobacillus fermentum CECT5716 (LC40), or L. coryniformis CECT5711 (K8) plus L. gasseri CECT5714 (LC9) (1:1) in spontaneously hypertensive rats (SHR) were evaluated.

METHODS AND RESULTS:

Ten Wistar Kyoto rats (WKY) and 30 SHR were randomly assigned to four groups (n = 10): a control WKY group, a control SHR groups, an SHR group treated with LC40, and an SHR treated with K8/LC9 group for 5 weeks (at a dose of 3.3 × 10(10) colony-forming units/day in drinking water). Long-term administration of probiotics reduced systolic blood pressure. The consumption of K8/LC9 mixture significantly reduced the cardiac and renal hypertrophy. Both groups of probiotics reversed the impaired aortic endothelium-dependent relaxation to acetylcholine observed in SHR. They also abolished the increased aortic superoxide levels by reducing the increased toll-like receptor-4 mRNA levels and NADPH oxidase activity found in SHR. K8/LC9 consumption also increased endothelial nitric oxide synthase phosphorylation. Probiotic treatments induced a change in the cecum microbiota of SHR, with higher counts of the Lactobacillus spp. cluster, and lower counts of Bacteriodes spp. and Clostridium spp.

CONCLUSION:

Probiotics exert cardiovascular protective effects in genetic hypertension related to the improvement of vascular pro-oxidative and pro-inflammatory status.

KEYWORDS:

Endothelial dysfunction; Gut microbiota; Hypertension; Probiotic bacteria; SHR

PMID:
26255877
DOI:
10.1002/mnfr.201500290
[Indexed for MEDLINE]
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