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Sci Rep. 2015 Aug 10;5:12800. doi: 10.1038/srep12800.

Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.

Author information

1
1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan [3] Research Fellow of the Japan Society for the Promotion of Science.
2
Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, 1-78 Shoumachi, Tokushima 770-8505, Japan.
3
1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan.
4
Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
5
1] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan [2] Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Japan.

Abstract

We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.

PMID:
26255701
PMCID:
PMC4530460
DOI:
10.1038/srep12800
[Indexed for MEDLINE]
Free PMC Article

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