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Clin Chim Acta. 2015 Oct 23;450:83-9. doi: 10.1016/j.cca.2015.08.002. Epub 2015 Aug 6.

Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction.

Author information

1
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China.
2
Department of Thoracic Surgery, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
3
Department of Health Care, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
4
Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. Electronic address: gaolinggen@163.com.
5
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China. Electronic address: zhouxianliang0326@hotmail.com.

Abstract

Advancing age is a major risk factor for the development of cardiovascular diseases. The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q10 (CoQ10) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria. Furthermore, in cardiac patients, plasma CoQ10 has been found to be an independent predictor of mortality. Based on the fundamental role of CoQ10 in mitochondrial bioenergetics and its well-acknowledged antioxidant properties, several clinical trials evaluating CoQ10 have been undertaken in cardiovascular disorders of ageing including chronic heart failure, hypertension, and endothelial dysfunction. CoQ10 as a therapy appears to be safe and well tolerated.

KEYWORDS:

Coenzyme Q10; Endothelial dysfunction; Heart failure; Hypertension

PMID:
26254995
DOI:
10.1016/j.cca.2015.08.002
[Indexed for MEDLINE]

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