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Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):725-32. doi: 10.1016/j.oooo.2015.06.028. Epub 2015 Jul 3.

EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS.

Author information

1
Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, South Africa.
2
Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, South Africa. Electronic address: Willie.vanheerden@up.ac.za.

Abstract

OBJECTIVE:

To present 2 cases of Epstein-Barr virus (EBV)-positive mucocutaneous ulcer of the oral mucosa in association with human immunodeficiency virus infection.

STUDY DESIGN:

Two recently diagnosed cases of EBV-positive mucocutaneous ulcer of the oral mucosa in patients with human immunodeficiency virus (HIV) were reviewed with regard to their clinical, histomorphologic, and immunophenotypic features.

RESULTS:

Both cases presented clinically as well-circumscribed ulcers that were histomorphologically characterized by dense superficial polymorphous inflammatory infiltrates. The infiltrates comprised cells with a predominant B-cell phenotype that ranged in size from small to intermediate with occasional large immunoblastic forms. Some of the larger B cells had a Reed-Sternberg-like morphology. The B cells were positive for CD20 and coexpressed CD30 and to a lesser extent CD15. Epstein-Barr virus-encoded small RNA (EBER) positivity was detected in most of the B cells.

CONCLUSIONS:

EBV-positive mucocutaneous ulcer represents an unusual form of lymphoproliferative disorder associated with immune suppression. It should be distinguished from other forms of HIV-associated oral ulceration.

PMID:
26254983
DOI:
10.1016/j.oooo.2015.06.028
[Indexed for MEDLINE]

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