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Ann Epidemiol. 2015 Oct;25(10):785-7. doi: 10.1016/j.annepidem.2015.06.002. Epub 2015 Jun 19.

The association of body shape trajectories over the life course with type 2 diabetes risk in adulthood: a group-based modeling approach.

Author information

1
Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, Villejuif, France; Paris-South University, Villejuif, France. Electronic address: guy.fagherazzi@gustaveroussy.fr.
2
Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, Villejuif, France; Paris-South University, Villejuif, France.
3
CHU Rennes, Rennes, France; Inserm U970, Paris, France.

Abstract

PURPOSE:

Low birth weight is a well-recognized risk factor for type 2 diabetes (T2D), but less is known about risks associated with the evolution of body shape throughout life with incident T2D in adulthood.

METHODS:

In 80,110 women from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort study, trajectories of self-reported body shapes from age 8 years to 35-40 years were derived using a group-based modeling approach and studied in relation with incident T2D.

RESULTS:

Compared with women who maintained a stable midrange body shape trajectory from 8 to 40 years, women in all other observed trajectories were at a higher risk of developing T2D in adulthood: The highest risk was observed for women who were lean at age 8 years and had a sharp increase in body shape (hazards ratio = 2.91 [2.35-3.62]); their T2D risk was higher (P for homogeneity = .059) than for women who maintained the largest body shape (hazards ratio = 2.18 [1.76-2.69]).

CONCLUSIONS:

A group-based modeling approach has identified trajectories of body shape evolution with different risks of developing T2D in adulthood. A sharp increase in body shape after puberty in previously lean girls is a risk factor for the subsequent development of diabetes.

KEYWORDS:

Adulthood; Body shape; Childhood; Cohort; Group-based modeling; Life course; Risk; Trajectory; Type 2 diabetes

PMID:
26254818
DOI:
10.1016/j.annepidem.2015.06.002
[Indexed for MEDLINE]
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