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Microvasc Res. 2015 Nov;102:19-24. doi: 10.1016/j.mvr.2015.07.007. Epub 2015 Aug 4.

A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study.

Collaborators (115)

Airò P7, Alegre-Sancho JJ8, Allanore Y9, Ananieva LP10, Ancuta C11, Andrade LE12, Aringer M13, Becvar R14, Bojinca M15, Butrimiene I16, Cantatore FP17, Caporali R18, Caramaschi P19, Carreira PE20, Chirieac R11, Corrado A17, Cosentino V21, Cuomo G22, Czirjak L23, Da Silva JA24, la Peña Lefebvre PG25, De Keyser F10, de Souza Müller C26, Damgaard K27, Damjanov N28, Denisov LN10, Distler O29, Doube A30, Dumitrascu A31, Engelhart M32, Exposito MV25, Eyerich K33, Farge-Bancel D32, Azevedo VF26, Foti R28, Frerix M34, Gabrielli A35, Garen T36, Gottschalk P37, Groseanu L38, Guiducci S39, Günther C40, Hachulla E30, Hein R33, Heitmann S41, Henes J42, Hesselstrand R43, Highton J44, Iannone F45, Ionescu RM38, Kayser C12, Karpec D16, Kerzberg E21, Kotulska A46, Kopec-Medrek M46, Kucharz E46, Krummel-Lorenz B47, Lauffer F33, Launay D30, Li M48, Litinsky I49, Loyo E37, Cerinic MM39, Meroni P50, Midtvedt Ø36, Mihai CM15, Montecucco C18, Montoya F21, Morgiel E51, Mouthon L52, Müller-Ladner U34, Nielsen H27, Opris D38, Ortiz-Santamaria V53, Otsa K54, Pileckyte M55, Pisarri S56, Popescu M31, Pozzi MR57, Puppo F58, Radominski SC33, Riccieri V59, Rosato E56, Rozman B60, Rubio SR25, Rugiene R16, Saar P47, Salvador MJ24, Seidel M61, Sokolik R51, Solanki K62, Stamenkovic B63, Stankovic A63, Stebbings S44, Strauss G27, Sulli A10, Szamosi S64, Szechinski J51, Szmyrka-Kaczmarek M51, Szücs G64, Tanaseanu CM31, Tiglea I31, Tyndall A65, Ughi N8, Uprus M54, Vacca A66, Varju C23, Venalis A16, Venalis P16, Walker UA65, Widuchowska M46, Wiland P51, Wuttge DM43, Zeni S8, Zenone T67.

Author information

1
Dept. of Clinical Sciences & Community Health, University of Milano, Milano, Italy; Division of Rheumatology, Istituto Gaetano Pini, Milano, Italy. Electronic address: francesca.ingegnoli@unimi.it.
2
Dept. of Clinical Sciences & Community Health, University of Milano, Milano, Italy; Medical Statistics and Biometry, Milano, Italy.
3
Division of Rheumatology, Istituto Gaetano Pini, Milano, Italy.
4
University of Ghent, Department of Rheumatology, Gent University Hospital, Gent, Belgium.
5
Research Laboratory and Academic Division of Clinical Rheumatology, University of Genova, Genova, Italy.
6
Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany.
7
UOC Reumatologia e Immunologia Clinica, Spedali Civili, Brescia, Italy.
8
Hospital Universitario Dr Peset, Valencia, Spain.
9
Rheumatology A dpt, Paris 5 University, Cochin Hospital, Paris, France.
10
Institute of Rheumatology, Russian Academy of Medical Science, Moscow, Russia.
11
Division of Rheumatology & Rehabilitation, GR.T. Popa Center for Biomedical Research, European Center for Translational Research-GR.T. Popa University of Medicine and Pharmacy Rehabilitation Hospital, Iasi, Romania.
12
Universidade Federal de São Paulo, Disciplina de Reumatologia, São Paulo, SP, Brazil.
13
Division of Rheumatology, Department of Medicine III, Dresden, Germany.
14
Institute of Rheumatology, 1st Medical School, Charles University, Praha, Czech Republic.
15
Department of Internal Medicine and Rheumatology, Clinic Ion Cantacuzino Clinical Hospital, Strada Ion Movila, Bucharest, Romania.
16
State Research Institute for Innovative Medicine, Vilnius University, Vilnius, Lithuania.
17
U.O. Reumatologia, Università degli Studi di Foggia, Ospedale Col. D'Avanzo, Foggia, Italy.
18
Unità Operativa e Cattedra di Reumatologia, IRCCS Policlinico S Matteo, Pavia, Italy.
19
Unità di Reumatologia AOUI Verona, Italy.
20
Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid, Spain.
21
Osteoarticular Diseases and Osteoporosis Centre, Pharmacology and Clinical Pharmacological Research Centre, School of Medicine, University of Buenos Aires, Rheumatology and Collagenopathies Department, Ramos Mejía Hospital, Buenos Aires, Argentina.
22
Dipartimento Medicina Clinica e Sperimentale F. Magrassi II Policlinico U.O. Reumatologia, Napoli, Italy.
23
Department of Immunology and Rheumatology, Faculty of Medicine, University of Pécs, Pécs, Akác u.l., Hungary.
24
Rheumatology Department, Hospitais da Universidade, Coimbra, Portugal.
25
Hospital Universitario Madrid Norte Sanchinarro, Madrid, Spain.
26
Hospital de Clínicas da Universidade Federal do Paraná, Paraná, Brazil.
27
Department of Rheumatology, University Hospital of Gentofte, Hellerup, Denmark.
28
U.O. di Reumatologia, A.O.U. Policlinico Vittorio Emanuele, Catania, Italy.
29
Division of Rheumatology, University Hospital, Zurich, Switzerland.
30
Department of Internal Medicine Hôpital Claude Huriez, Lille cedex, France.
31
Clinical Emergency Hospital St. Pantelimon, Bucharest, Romania.
32
Department of Internal Medicine, Hopital Saint-Louis, Avenue Claude Vellefaux, Paris, France.
33
Department of Dermatology and Allergy of the TU Munich, Munich, Germany.
34
Lehrstuhl für Innere Medizin mit Schwerpunkt Rheumatologie der Justus-Liebig-Universität Giessen, Abteilung für Rheumatologie und Klinische Immunologie Kerckhoff-Klinik Bad Nauheim, Bad Nauheim, Germany.
35
Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Università Politecnica delle Marche, University of Ancona, Ancona, Italy.
36
Department of Rheumatology, Rikshospitalet University Hospital Sognsvannveien, Oslo, Norway.
37
Reumatologia e Inmunologia Clinica, Hospital Regional Universitario Jose Ma Cabral y Baez, Santiago, Dominican Republic.
38
Department of Rheumatology, St. Maria Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
39
University of Florence, Department of Bio-Medicine, Division of Rheumatology, Florence, Italy.
40
Department of Dermatology, University Medical Center Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.
41
Department of Rheumatology, Marienhospital Stuttgart, Stuttgart, Germany.
42
Medizinische Universitätsklinik, Abt. II (Onkologie, Hämatologie, Rheumatologie Immunologie, Pulmonologie), Tübingen, Germany.
43
Department of Rheumatology, Lund University Hospital, Lund, Sweden.
44
Dunedin School of Medicine, Dunedin, New Zealand.
45
U.O. Reumatologia Università degli Studi di Bari, Azienda Ospedaliera, Policlinico, Bari, Italy.
46
Department of Internal Medicine and Rheumatology, University of Silesia, Katowice, Poland.
47
Endokrinologikum Frankfurt, Frankfurt, Germany.
48
Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
49
Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
50
UOC Reumatologia e Immunologia Clinica, Spedali Civili, Brescia, Italy; Hospital Universitario Dr Peset, Valencia, Spain.
51
Department of Rheumatology and Internal Diseases, Wroclaw University of Medicine, Wroclaw, Poland.
52
Department of Internal Medicine, Pr Loïc Guillevin Hôpital Cochin, Paris, France.
53
Rheumatology Granollers General Hospital, Granollers, Barcelona, Spain.
54
East-Tallin Central Hospital, Department of Rheumatology, Tallin, Estonia.
55
Kaunas University of Medicine Hospital, Department of Rheumatology, Lithuania.
56
Centro per la Sclerosi Sistemica, Dipartimento di Medicina Clinica, Università La Sapienza, Policlinico Umberto I, Roma, Italy.
57
Dipartimento di Medicina, Ospedale San Gerardo, Monza, Italy.
58
Clinica di Medicina Interna ad orientamento immunologico-Università di Genova, IRCCS Azienda Ospedaliero-Universitaria,Università San Martino, Genova, Italy.
59
Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma La Sapienza, Roma, Italy.
60
University Medical Center Ljublijana, Division of Internal Medicine, Department of Rheumatology, Ljubliana, Slovenia.
61
Medizinische Universitäts-Poliklinik, Dep. of Rheumatology, Bonn, Germany.
62
Waikato University Hospital Rheumatology Unit, Hamilton City, New Zealand.
63
Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Disease Niska Banja, Niska Banja, Serbia.
64
Third Department of Medicine, Rheumatology Division, University of Debrecen Medical Center, Hungary.
65
Unispital Basel, Basel, Switzerland.
66
II Chair of Rheumatology, University of Cagliari, Policlinico Universitario, Monserrato (CA), Italy.
67
Department of Medicine, Unit of Internal Medicine, Valence cedex, France.

Abstract

OBJECTIVE:

Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database.

METHODS:

Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile.

RESULTS:

30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56.

CONCLUSION:

This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

KEYWORDS:

Capillaroscopy; EUSTAR; Juvenile systemic sclerosis; Microcirculation; Nailfold capillaroscopy; Systemic sclerosis; Videocapillaroscopy

PMID:
26254260
DOI:
10.1016/j.mvr.2015.07.007
[Indexed for MEDLINE]

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