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J Cell Commun Signal. 2016 Mar;10(1):61-7. doi: 10.1007/s12079-015-0302-x. Epub 2015 Aug 8.

A network map of Interleukin-10 signaling pathway.

Author information

1
International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India.
2
School of Biotechnology, KIIT University, Bhubaneswar, Odisha, 751 024, India.
3
Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
4
Manipal University, Madhav Nagar, Manipal, 576 104, India.
5
YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India.
6
Department of Microbiology, National JALMA Institute for Leprosy & Other Mycobacterial Diseases (Indian Council of Medical Research), Agra, 282 004, India.
7
McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD, USA.
8
Departments of Biological Chemistry, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD, 21205, USA.
9
Departments of Oncology, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD, 21205, USA.
10
Departments of Pathology, Johns Hopkins University School of Medicine, 733N. Broadway, Baltimore, MD, 21205, USA.
11
CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110 020, India.
12
International Technology Park, Whitefield,, Institute of Bioinformatics, Bangalore, 560 066, India. keshav@ibioinformatics.org.
13
NIMHANS-IOB Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India. keshav@ibioinformatics.org.
14
YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India. keshav@ibioinformatics.org.
15
Command Hospital (Air Force), Bangalore, 560 007, India. shankarsid@gmail.com.

Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer. In addition, it plays a central role in survival and persistence of intracellular pathogens such as Leishmania donovani, Mycobacterium tuberculosis and Trypanosoma cruzi inside the host. The signaling mechanisms of IL-10 cytokine are not well explored and a well annotated pathway map has been lacking. To this end, we developed a pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature. The reactions were categorized under molecular associations, activation/inhibition, catalysis, transport and gene regulation. In all, 37 molecules and 76 reactions were annotated. The IL-10 signaling pathway can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by our group.

KEYWORDS:

Co-stimulatory molecules; Interferon-gamma (IFN-γ); Lipopolysaccharides; NetSlim; Pro-inflammatory cytokines; Protein-protein interactions; Systems biology markup language; Translocation

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