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Vet Pathol. 2016 May;53(3):621-4. doi: 10.1177/0300985815598207. Epub 2015 Aug 7.

Nasal Cavity Masses Resembling Chondro-osseous Respiratory Epithelial Adenomatoid Hamartomas in 3 Dogs.

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University of California, School of Veterinary Medicine, Davis, CA, USA
University of California, School of Veterinary Medicine, Davis, CA, USA.
University of Chile, Faculty of Veterinary and Animal Sciences, Santa Rosa, La Pintana, Santiago, Chile.


Chondro-osseous respiratory epithelial adenomatoid hamartomas (COREAHs) are rare tumors in the nasal cavity of people, which have not been described in other species. COREAHs in people are minimally invasive and rarely recur following excision. Histologically, these tumors are composed of disorganized, mature, nasal turbinate tissue that is organized into polypoid growths. These growths are lined by respiratory epithelium, contain glandular elements, and are organized around central cores of chondro-osseous matrix. This report describes 3 cases of dogs with nasal tumors that have histomorphology similar to that of COREAH in people. The tumors were all identified within the nasal cavity and were associated with regional bony lysis of the turbinates and surrounding skull bones, a feature that has not been reported in COREAH in people. There was no evidence of metastasis or extension beyond the nasal cavity in any of the 3 cases.


dog; epistaxis; exophthalmos; hamartoma; histology; nasal sinus; pathology; respiratory

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