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Brain Res. 2015 Dec 2;1628(Pt A):2-16. doi: 10.1016/j.brainres.2015.07.047. Epub 2015 Aug 4.

Corticostriatal microRNAs in addiction.

Author information

1
Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, United States.
2
Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, United States. Electronic address: paul.kenny@mssm.edu.

Abstract

Addiction is a chronically relapsing disorder characterized by compulsive drug use in spite of adverse consequences. Currently, there are very few effective treatments for addiction; in order to develop novel therapies, a clearer understanding of mechanisms underlying addiction is needed. Drugs of abuse induce lasting adaptations in corticostriatal and mesolimbic brain reward circuitry due to long-term alterations in gene expression. microRNAs, a class of non-coding RNAs, are powerful regulators of gene expression that bind to target mRNAs, thereby inhibiting their translation and/or causing degradation. miRNAs are increasingly implicated in gene expression changes underlying normal neuronal function as well as dysfunctions such as addiction and psychiatric disorders. This review summarizes plasticity- and drug-related miRNA expression patterns and functions in the context of corticostriatal circuitry, while proposing future directions that may reveal miRNA-mediated mechanisms regulating addiction-related behaviors in vivo.

KEYWORDS:

Addiction; MicroRNA; Plasticity

PMID:
26253823
DOI:
10.1016/j.brainres.2015.07.047
[Indexed for MEDLINE]

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