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Bioorg Med Chem Lett. 2015 Sep 15;25(18):3816-21. doi: 10.1016/j.bmcl.2015.07.077. Epub 2015 Jul 26.

Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies.

Author information

1
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA; Department of Chemistry & Physics, Georgia Reagents University, Augusta, GA 30912, USA. Electronic address: sspanda12@gmail.com.
2
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
3
Pesticide Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
4
Microbiology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
5
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.

Abstract

Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.

KEYWORDS:

Amino acids; Anti-bacterial; Conjugates; Fluoroquinolone; QSAR; Quinolone

PMID:
26253630
DOI:
10.1016/j.bmcl.2015.07.077
[Indexed for MEDLINE]

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