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Clin Perinatol. 2015 Sep;42(3):651-73. doi: 10.1016/j.clp.2015.04.010.

Thrombosis in the Neonatal Intensive Care Unit.

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Division of Neonatology, Levine Children's Hospital at Carolinas Medical Center, 1000 Blythe Boulevard, 7th Floor, Charlotte, NC 28203, USA. Electronic address:


Neonates have the highest risk for pathologic thrombosis among pediatric patients. A combination of genetic and acquired risk factors significantly contributes to this risk, with the most important risk factor being the use of central venous catheters. Proper imaging is critical for confirming the diagnosis. Despite a significant number of these events being life- and limb-threatening, there is limited evidence on what the appropriate management strategy should be. Evaluation and treatment of any neonate with a clinically significant thrombosis should occur at a tertiary referral center that has proper support.


Anticoagulation; Cerebral sinovenous thrombosis; Neonatal thrombosis; Perinatal arterial ischemic stroke; Prothrombotic disorder; Thrombolysis

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