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Clin Nutr. 2016 Aug;35(4):812-8. doi: 10.1016/j.clnu.2015.06.010. Epub 2015 Jul 15.

Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial.

Author information

1
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy.
2
Hematology Laboratory, University Hospital CHU, 9 Quai Moncousu, 44000 Nantes, France.
3
Biostatistical Center INRCA, Via S. Margherita 5, 60100 Ancona, Italy.
4
Experimental Medicine Department, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
5
Institute for Organic Synthesis and Photoreactivity, National Research Council of Italy, CNR, (ISOF), Via P. Gobetti 101, 40129 Bologna, Italy.
6
Department of Chemistry, University Mohammed V-Agdal, Rabat, Morocco.
7
Department Gastroenterology and Hepatology, Charité-Universitätsmedizin Berlin, CCM, Charitéplatz 1, 10117 Berlin, Germany.
8
Medical University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria.
9
CHU Bordeaux, Clinical Gerontology, France; CNRS, RMSB, UMR 5536, France; University Bordeaux, RMSB, UMR 5536, Bordeaux, France.
10
R&D, VoxNet CEO, Via Giovanni Paisiello 32, 00198 Rome, Italy.
11
Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
12
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy; IRCCS, Institute of Neurological Sciences, Via Altura 3, 40139 Bologna, Italy; National Research Council of Italy, CNR, Institute for Organic Synthesis and Photoreactivity (ISOF), Via P. Gobetti 101, 40129 Bologna, Italy.
13
Biopark Campus Cancer, 1 mail du Pr Georges Mathé, 94807 Villejuif, France. Electronic address: endocell@wanadoo.fr.

Abstract

BACKGROUND & AIMS:

Eating habits may influence the life span and the quality of ageing process by modulating inflammation. The RISTOMED project was developed to provide a personalized and balanced diet, enriched with or without nutraceutical compounds, to decrease and prevent inflammageing, oxidative stress and gut microbiota alteration in healthy elderly people. This paper focused on the effect on inflammation and metabolism markers after 56 days of RISTOMED diet alone or supplementation with three nutraceutical compounds.

METHODS:

A cohort of 125 healthy elderly subjects was recruited and randomized into 4 arms (Arm A, RISTOMED diet; Arm B, RISTOMED diet plus VSL#3 probiotic blend; Arm C, RISTOMED diet plus AISA d-Limonene; Arm D, RISTOMED diet plus Argan oil). Inflammatory and metabolism parameters as well as the ratio between Clostridium cluster IV and Bifidobacteria (CL/B) were collected before and after 56 days of dietary intervention, and their evolution compared among the arms. Moreover, participants were subdivided according to their baseline inflammatory parameters (erythrocytes sedimentation rate (ESR), C-Reactive Protein, fibrinogen, Tumor Necrosis Factor-alfa (TNF-α), and Interleukin 6) in two clusters with low or medium-high level of inflammation. The evolution of the measured parameters was then examined separately in each cluster.

RESULTS:

Overall, RISTOMED diet alone or with each nutraceutical supplementation significantly decreased ESR. RISTOMED diet supplemented with d-Limonene resulted in a decrease in fibrinogen, glucose, insulin levels and HOMA-IR. The most beneficial effects were observed in subjects with a medium-high inflammatory status who received RISTOMED diet with AISA d-Limonene supplementation. Moreover, RISTOMED diet associated with VSL#3 probiotic blend induced a decrease in the CL/B ratio.

CONCLUSIONS:

Overall, this study emphasizes the beneficial anti-inflammageing effect of RISTOMED diet supplemented with nutraceuticals to control the inflammatory status of elderly individuals.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01069445 NCT01179789.

KEYWORDS:

Ageing; Diet; Inflammation; Nutraceutics; Probiotics; d-Limonene

PMID:
26249791
DOI:
10.1016/j.clnu.2015.06.010
[Indexed for MEDLINE]

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