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Bioessays. 2015 Sep;37(9):1005-15. doi: 10.1002/bies.201500054. Epub 2015 Aug 6.

Noncoding RNAs and chronic inflammation: Micro-managing the fire within.

Author information

1
Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT, USA.

Abstract

Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age-associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets.

KEYWORDS:

aging; autoimmunity; chronic inflammation; miRNAs; noncoding RNA

PMID:
26249326
PMCID:
PMC5054901
DOI:
10.1002/bies.201500054
[Indexed for MEDLINE]
Free PMC Article

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